What is CBD?

Cannabidiol [commonly known as CBD], is a non-psychoactive component of the marijuana hemp plant. CBD recently generated a slew of interest among many medical scientists and physicians throughout the years, however, exerts in the field of CBD science are exemplifying its therapeutic effects on a molecular level. Cannabidiol is a pleiotropic drug, which means that it creates a multitude of effects through various molecular pathways.

CBD is known to have a small binding effect with both of the two cannabinoid receptors (known as CB1 and CB2). CBD oil also activates a handful of non-cannabinoid receptors and ion-channels. In addition, CBD plays a role in different receptor independent channels by pausing the re-uptake of endogenous neurotransmitters. These include anandamide and adenosine. This process enhanced or inhibits the binding behavior of particular G-coupled protein receptors. So what does all this really mean?

Here are some of the ways that CBD confers its manifold therapeutic effects.

Serotonin Receptors
A group including Jose Crippa and colleagues at Kings College in London conducted initial studies with Cannabidiol and the effects on anxiety. At high levels of concentrations, Cannabidiol stimulates and activates the 5-HT1A (hydroxytryptamine) Serotonin receptors. This inhibits anxiety and allows for a much more relaxed mood. The G-coupled protein receptor also effects a slew of other biological as well as neurological behaviors which include improvements in helping with anxiety, physical and mental addictions, loss of appetite, sleep insomnia, chronic pain, nausea and vomiting.

Vanilloid Receptors
Cannabidiol works one-on-one with numerous ion pathways to build a therapeutic effect on the body. Cannabidiol combines with the TRPV-1 receptors allowing for positive functions within various ion-channels. TRPV-1 has been found to work with pain perception, reduction of inflammation, and body temperature.

Anti-Inflammatory & Anti-Anxiety

Cannabidiol is known to help with reducing inflammation as well as anxiety, which are both attributable to their inhibition of the adenosine re-uptake. This happens when delays in the reuptake process of this neurotransmitter. Cannabidiol then increases the adenosine levels within the neurological system in the brain, further regulating adenosine receptor-activity. Both A1-A and A2-A (adenosine receptors) offer very significant roles in the cardiovascular functions of the body. These systems are known to regulate the myocardial oxygen usages and heart blood flow. In summary, al of these bodily receptors offer a wide range of anti-inflammatory effects throughout the entire body.